Biotech / Pharmaceutical

Biotech / Pharmaceutical

Cell growth is a complex process.  Pharmaceutical manufacturing, which relies on the production of live cells, requires balancing the amounts of intake nutrients and accounting for the metabolic processes and metabolites produced during growth.  Very often, cell-based production is a very high-cost manufacturing process so waste avoidance and process optimization are crucial.

The use of spectroscopic sensors for bioprocess monitoring is a powerful tool as a mechanism to design, analyze and control the pharmaceutical manufacturing process through the measurement of critical process parameters which will affect critical quality attributes.  In-line measurements are particularly  important during the cost-intensive manufacturing of biopharmaceuticals in order to facilitate any early process fault detection.  This will help to minimize the risk of contamination and observe real time product release.

Featured Applications

Biocatalytic Synthesis

Measurements in Laboratories

Process monitoring of biocatalytic synthesis of a non-steroidal anti-inflammatory drug. The reaction of interest is the biocatalyzed synthesis of the drug.

With our Raman spectrometer immersed in the reaction mixture, the spectrometer is an excellent option for inline monitoring of biocatalytic synthesis in aqueous solution without spectral disturbance caused by water.

CHO Cell Cultivation

Bioprocess of CHO cell cultivation

Bioprocess monitoring of CHO cell cultivations.

Our non-contact Raman Process Spectrometer System is used for monitoring of CHO cell cultivations for monoclonal antibody production in a 2L stirred tank bioreactor. 

  • Raman spectra obtain chemical information about the bioprocess.
  • Spectral trajectory can be measured through the glass.
  • Baseline shift comprises information about the cell concentration.
  • No reference data needed – only spectral data.
  • Detect deviations from standard batches.

Oxygen Deficiency Monitoring

Oxygen Deficiency Monitoring in Lab

Regardless of the application of the compressed gas in the laboratory, if the gas is stored in any volume, then any leak in the storage or distribution systems or an unplanned release of the inert gas will quickly displace the normal atmospheric oxygen within the lab. Oxygen concentration can rapidly drop to dangerous level resulting in asphyxiation or death of lab personnel.

Our Oxygen Deficiency Monitor will detect low oxygen levels in the atmosphere and sound an alarm to alert individuals in the area to the danger.

Glove Box

Laboratory Glove Box

A glove box in a laboratory is a system that establishes a controlled environment, separate from the surrounding atmosphere in which materials can be manipulated. Maintaining an atmosphere that is almost void of oxygen (O2) is critical when storing and manipulating reactive substances within a glovebox.

Our specialized oxygen (O2) analyzers are ideal for detecting ppm or “trace” level of oxygen within these enclosed atmosphere.